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What (who) is hypoxic$37119$ - definition
![How the HTi is calculated: Only part of the IHT session is shown, the targeted [[SpO2]] value is 80% as an example. The filled part of the [[SpO2]] graph represents the amount of hypoxia delivered, “dosage”.](https://commons.wikimedia.org/wiki/Special:FilePath/HTi Graph.png?width=200 "How the HTi is calculated: Only part of the IHT session is shown, the targeted [[SpO2]] value is 80% as an example. The filled part of the [[SpO2]] graph represents the amount of hypoxia delivered, “dosage”.")
![[[Cusco]], Peru, which has an altitude of 11,000 ft](https://commons.wikimedia.org/wiki/Special:FilePath/Cuzco-Pano edit.jpg?width=200 "[[Cusco]], Peru, which has an altitude of 11,000 ft")
Wikipedia
Tumor hypoxia is the situation where tumor cells have been deprived of oxygen. As a tumor grows, it rapidly outgrows its blood supply, leaving portions of the tumor with regions where the oxygen concentration is significantly lower than in healthy tissues. Hypoxic microenvironements in solid tumors are a result of available oxygen being consumed within 70 to 150 μm of tumour vasculature by rapidly proliferating tumor cells thus limiting the amount of oxygen available to diffuse further into the tumor tissue. In order to support continuous growth and proliferation in challenging hypoxic environments, cancer cells are found to alter their metabolism. Furthermore, hypoxia is known to change cell behavior and is associated with extracellular matrix remodeling and increased migratory and metastatic behavior.
